Peer Data Management

Peer Data Management (PDM) deals with the management of structured data in unstructured peer-to-peer (P2P) networks. Each peer can store data locally and define relationships between its data and the data provided by other peers. Queries posed to any of the peers are then answered by also considering the information implied by those mappings. The overall goal of PDM is to provide semantically well-founded integration and exchange of heterogeneous and distributed data sources. Unlike traditional data integration systems, peer data management systems (PDMSs) thereby allow for full autonomy of each member and need no central coordinator. The promise of such systems is to provide flexible data integration and exchange at low setup and maintenance costs. However, building such systems raises many challenges. Beside the obvious scalability problem, choosing an appropriate semantics that can deal with arbitrary, even cyclic topologies, data inconsistencies, or updates while at the same time allowing for tractable reasoning has been an area of active research in the last decade. In this survey we provide an overview of the different approaches suggested in the literature to tackle these problems, focusing on appropriate semantics for query answering and data exchange rather than on implementation specific problems

Überprüfung von Düngungsstrategien zur Optimierung der Stickstoffdüngung für Weizen und Roggen zur Produktion von Ethanol durch dreijährige Feldversuche

In den Jahren 2008 bis 2010 wurden in Brandenburg, im Leibniz-Zentrum für Agrarlandschaftsforschung (ZALF) e.V. in Müncheberg, N-Düngungsversuche mit Winterweizen und Winterroggen durch-geführt. Untersucht wurde, inwieweit Kornertrag und Stärkegehalt von Menge und Zeitpunkt der Düngung sowie der Art des Stickstoffdüngers abhängen. Geprüft wurden dabei die Dünger Kalkammonsalpeter und Harnstoff, „stabilisiert“ mit Nitrifikationshemmer. Sowohl bei Roggen als auch bei Weizen wird der Stärkeertrag nur wenig durch die verschiedenen N-Düngungsvarianten beeinflusst. Nur der Unterschied zu den ungedüngten Varianten ist signifikant. Der Stärkegehalt im Korn nimmt bei Weizen und Roggen mit zunehmendem Kohlenstoff- und Proteingehalt ab. Hohe N-Versorgung des Getreides kann somit den Stärkegehalt aufgrund einer Förderung des Eiweißgehaltes senken

Optical and Infrared Photometry of the Type Ia Supernovae 1999da, 1999dk, 1999gp, 2000bk, and 2000ce

We present BVRI photometry of the Type Ia supernovae 1999da, 1999dk, 1999gp, 2000bk, and 2000ce, plus infrared photometry of three of these. These objects exhibit the full range of decline rates of Type Ia supernovae. Combined optical and infrared data show that families of V - infrared color curves can be used to derive the host extinction (A_V) of these objects. Existing data do not yet allow us to construct these loci for all color indices and supernova decline rates, but the V-K color evolution is sufficiently uniform that it allows the determination of host extinction over a wide range of supernova decline rates to an accuracy of roughly +/- 0.1 mag. We introduce a new empirical parameter, the mean I-band flux 20 to 40 days after maximum light, and show how it is directly related to the decline rate.Comment: 53 pages, 18 figures, accepted for publication in the Astronomical Journal (scheduled for the September 2001 issue

SN 2009bb: a Peculiar Broad-Lined Type Ic Supernova

Ultraviolet, optical, and near-infrared photometry and optical spectroscopy of the broad-lined Type Ic supernova (SN) 2009bb are presented, following the flux evolution from -10 to +285 days past B-band maximum. Thanks to the very early discovery, it is possible to place tight constraints on the SN explosion epoch. The expansion velocities measured from near maximum spectra are found to be only slightly smaller than those measured from spectra of the prototype broad-lined SN 1998bw associated with GRB 980425. Fitting an analytical model to the pseudo-bolometric light curve of SN 2009bb suggests that 4.1+-1.9 Msun of material was ejected with 0.22 +-0.06 Msun of it being 56Ni. The resulting kinetic energy is 1.8+-0.7x10^52 erg. This, together with an absolute peak magnitude of MB=-18.36+-0.44, places SN 2009bb on the energetic and luminous end of the broad-lined Type Ic (SN Ic) sequence. Detection of helium in the early time optical spectra accompanied with strong radio emission, and high metallicity of its environment makes SN 2009bb a peculiar object. Similar to the case for GRBs, we find that the bulk explosion parameters of SN 2009bb cannot account for the copious energy coupled to relativistic ejecta, and conclude that another energy reservoir (a central engine) is required to power the radio emission. Nevertheless, the analysis of the SN 2009bb nebular spectrum suggests that the failed GRB detection is not imputable to a large angle between the line-of-sight and the GRB beamed radiation. Therefore, if a GRB was produced during the SN 2009bb explosion, it was below the threshold of the current generation of gamma-ray instruments.Comment: Accepted for publication in Ap

Psychosocial primary care – what patients expect from their General Practitioners A cross-sectional trial

BACKGROUND: Psychosocial Primary Care (PPC) is a model of service delivery for patients with mental disorders and psychosocial problems which was established in Germany in 1987. This study was performed as part of the evaluation of a PPC training program. We investigated patients' expectations of the psychosocial treatment offered by GPs trained in PPC. METHODS: Ten general practitioners trained in PPC were randomly selected. Two hundred and twenty patients were surveyed in the waiting room regarding their expectations concerning psychological treatment. RESULTS: Eighty-five per cent of patients could envisage making use of psychosocial treatments. Counselling by the GP was considered most important (65%). Fifty-four per cent of patients indicated that there was sufficient counselling, but further distinctions revealed dissatisfaction with both the extent and content of the counselling. Lack of time was the most frequent reason (53%) cited for insufficient counselling. A willingness to discuss the psychological aspects of illness was exhibited by between 55% (current illness) and 79% of patients. Two-thirds of patients believed that discussing psychological aspects and counselling by the doctor could exert a healing effect or contribute to symptomatic improvement in physical illnesses. Younger patients and patients with experience in psychotherapy expected referral to mental health services. CONCLUSIONS: Primary care patients desire and accept psychological treatment from their GP. Training in psychosocial competence in primary care should be offered more frequently

Full-length haplotype reconstruction to infer the structure of heterogeneous virus populations

Next-generation sequencing (NGS) technologies enable new insights into the diversity of virus populations within their hosts. Diversity estimation is currently restricted to single-nucleotide variants or to local fragments of no more than a few hundred nucleotides defined by the length of sequence reads. To study complex heterogeneous virus populations comprehensively, novel methods are required that allow for complete reconstruction of the individual viral haplotypes. Here, we show that assembly of whole viral genomes of ∼8600 nucleotides length is feasible from mixtures of heterogeneous HIV-1 strains derived from defined combinations of cloned virus strains and from clinical samples of an HIV-1 superinfected individual. Haplotype reconstruction was achieved using optimized experimental protocols and computational methods for amplification, sequencing and assembly. We comparatively assessed the performance of the three NGS platforms 454 Life Sciences/Roche, Illumina and Pacific Biosciences for this task. Our results prove and delineate the feasibility of NGS-based full-length viral haplotype reconstruction and provide new tools for studying evolution and pathogenesis of viruse

Phenocopy – A Strategy to Qualify Chemical Compounds during Hit-to-Lead and/or Lead Optimization

A phenocopy is defined as an environmentally induced phenotype of one individual which is identical to the genotype-determined phenotype of another individual. The phenocopy phenomenon has been translated to the drug discovery process as phenotypes produced by the treatment of biological systems with new chemical entities (NCE) may resemble environmentally induced phenotypic modifications. Various new chemical entities exerting inhibition of the kinase activity of Transforming Growth Factor β Receptor I (TGF-βR1) were qualified by high-throughput RNA expression profiling. This chemical genomics approach resulted in a precise time-dependent insight to the TGF-β biology and allowed furthermore a comprehensive analysis of each NCE's off-target effects. The evaluation of off-target effects by the phenocopy approach allows a more accurate and integrated view on optimized compounds, supplementing classical biological evaluation parameters such as potency and selectivity. It has therefore the potential to become a novel method for ranking compounds during various drug discovery phases

Multi-Messenger Astronomy with Extremely Large Telescopes

The field of time-domain astrophysics has entered the era of Multi-messenger Astronomy (MMA). One key science goal for the next decade (and beyond) will be to characterize gravitational wave (GW) and neutrino sources using the next generation of Extremely Large Telescopes (ELTs). These studies will have a broad impact across astrophysics, informing our knowledge of the production and enrichment history of the heaviest chemical elements, constrain the dense matter equation of state, provide independent constraints on cosmology, increase our understanding of particle acceleration in shocks and jets, and study the lives of black holes in the universe. Future GW detectors will greatly improve their sensitivity during the coming decade, as will near-infrared telescopes capable of independently finding kilonovae from neutron star mergers. However, the electromagnetic counterparts to high-frequency (LIGO/Virgo band) GW sources will be distant and faint and thus demand ELT capabilities for characterization. ELTs will be important and necessary contributors to an advanced and complete multi-messenger network.Comment: White paper submitted to the Astro2020 Decadal Surve